An essential role of virus-infected B cells in the marmoset experimental autoimmune encephalomyelitis model:

Multiple Sclerosis Journal – Experimental, Translational and Clinical

Bert A ’t Hart¹  Yolanda S Kap² 

[1] Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands;Department of Neuroscience, University of Groningen Medical Center, The Netherlands

关键词: MS risk;    myelin oligodendrocyte glycoprotein processing;    autophagy;    citrullination;   

DOI  :  10.1177/2055217317690184

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Infection with Epstein–Barr virus (EBV) has been associated with an enhanced risk of genetically susceptible individuals to develop multiple sclerosis (MS). However, an explanation for the contrast between the high EBV infection prevalence (60–90%) and the low MS prevalence (0.1%) eludes us. Here we propose a new concept for the EBV–MS association developed in the experimental autoimmune encephalomyelitis model in marmoset monkeys, which are naturally infected with the EBV-related γ1-herpesvirus CalHV3. The data indicate that the infection of B cells with a γ1-herpesvirus endows them with the capacity to activate auto-aggressive CD8+ T cells specific for myelin oligodendrocyte glycoprotein.

【 授权许可】

CC BY-NC