The Antibacterial Effects of Antimicrobial Peptides OP-145 against Clinically Isolated Multi-Resistant Strains

Japanese journal of infectious diseases

Jian-An Huang¹  Liu Ming² 

[1] Department of Respiratory, Affiliated Hospital of Nanjing Medical University;Department of Respiratory, The First Affiliated Hospital of Suzhou University

关键词: Antimicrobial peptides;    Biofilm;    Antibacterial effects;   

DOI  :  10.7883/yoken.JJID.2017.090

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

OP-145 is a synthetic antimicrobial peptide developed from the human cathelicidin LL-37. The purpose of this investigation was to evaluate the effect of the antimicrobial peptide OP-145 against clinically isolated drug-resistant strains. Ten methicillin-resistant Staphylococcus aureus (MRSA) strains were obtained from our hospital's clinical inspection center, and the activity of OP-145 on growth and biofilm formation of these strains was evaluated by colony counts and scanning electron microscopy. The antimicrobial peptide OP-145 showed significant antibacterial activity against 9 MRSA strains. For the biofilm experiments, MRSA counts in the biofilms decreased significantly after 24 h (P ＜ 0.05). OP-145 strongly reduced growth and biofilm formation of clinically isolated drug-resistant strains in vitro, and the use of this class of antimicrobial agents may be an important new approach in controlling bacterial infections.

【 授权许可】

Unknown