Assessment of the in-vivo and in-vitro antioxidant potential of Strychnos potatorum Linn. seeds in Freunds adjuvant induced arthritic rats

Dynamic Chiropractic

Senthamil Selvan Perumal¹  Venkataraman Subramanian²  Sanmuga Priya Ekambaram³ 

[1] 620 024, India.;C.L. Baid Mehta Foundation for Pharmaceutical Education and Research, Jyoti Nagar, Old Mahabalipuram Road, Thorapakkam, Chennai 600 096, Tamilnadu, India.;Department of Pharmaceutical Technology, Anna University of Technology, Tiruchirappalli &ndash

关键词: Strychnos potatorum;    enzymic and non-enzymic antioxidants;    free radical scavenging;    lipid peroxidation.;   

DOI  :  

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

The Indian system of medicine providesStrychnos potatorumLinn. seeds for the treatment of various ailments like jaundice, bronchitis, diabetes, renal and vesicle calculi, conjunctivitis, chronic diarrhoea, dysentery etc. The present study involves the effect of crude powder (SPP) and aqueous extract (SPE) ofS. potatorumLinn seeds onin vivoantioxidant defense system against Freund’s complete adjuvant (FCA) induced arthritis in rats at the dose of 200 mg/kg/p.o for 14 and 28 days andin vitroantioxidant activity against Ferrous thiocyanate (FTC) and Thiobarbiturate (TBA) induced lipid peroxidation. The antioxidant defense system parameters studied in plasma and tissues of arthritic rats were found to be altered significantly. These alterations observed in arthritic rats may be due to the increased oxidative stress in the tissues, which were significantly reduced in SPP and SPE treated arthritic rats. The results reveal that, the drug treatment decreased the LPO levels in plasma and tissues, either by interception of the formation or by scavenging the active oxygen species. The raise in enzymic and nonenzymic antioxidants level may be due to the sparing effect of antioxidant defense system as the drugs SPP and SPE have scavenged the free radicals by various antioxidant phytochemicals like steroids, triterpenes and polyphenolics present in it either by individual or by combined action. Inin vitrototal antioxidant analysis by FTC and TBA methods, SPE was found to show higher antioxidant activity when compared with SPP.

【 授权许可】

Unknown