Inhibition of angiogenesis and metastasis of uveal melanoma cells by astragaloside IV

Dynamic Chiropractic

Zhang Wenjing¹  Wang Dong²  Tang Dongrun³  Ma Minwang⁴ 

[1]Affiliated Hospital of Medical College of Chinese People&rsquo

[2]The 2nd Hospital of Tianjin Medical University, Tianjin, China.

[3]Tianjin First Center Hospital, Tianjin, China.

[4]s Armed Police Forces, Tianjin, China.

关键词: Astragaloside IV;    anti-cancer;    vascular endothelial growth factor;    uveal melanoma.;   

DOI  :  10.5897/JMPR11.572

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Astragaloside IV (AS) has been recently shown to possess pharmacologic activities against cancer. Vascular endothelial growth factor (VEGF) plays a prominent role in the induction of physiological or pathophysiological processes of tumor angiogenesis. The present study focuses on the anti-angiogenesis effects of AS in uveal melanoma cells. In this study, AS was demonstrated to exhibit higher anti-proliferation activity against cultured uveal melanoma cells compared with control. AS was also found to inhibit VEGF-a expression and secretion in human cells; functional assays also indicated inhibition of invasion and migration of the cells. This provides new information on a significant anti-tumor effect of AS. This saponin may be used as a novel therapeutic drug for the inhibition of tumor angiogenesis and metastasis.

【 授权许可】

Unknown