Antibacterial, anti-inflammatory and antioxidant activities of anthraquinones from Ceratotheca triloba (Bernh) Hook F

Dynamic Chiropractic

关键词: Anthraquinone;    9;    10 anthracenedione;    1 hydroxy -4 methylanthraquinone;    antioxidant activity.;   

DOI  :  10.5897/JMPR12.900

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

9, 10-Anthracenedione and 1-hydroxy-4-methylanthraquinone showed antibacterial activity againstStaphylococcus aureus, Micrococcus luteus, Bacillus cereusandEscherichia coli. Due to the synergistic effect of the individual compounds, the crude extract from leaves and roots ofCeratotheca trilobaexhibited good potency (>500) againstS. aureusandM. luteus,medium potency againstE. coliandS. typhimurium(<100) and very low potency againstB. cereus(<10). Although a similar trend was observed for 9, 10 anthracenedione and 1-hydroxy -4-methyl anthraquinone unlike the crude extract. A very low potency againstS. aureuswas observed for 9, 10 anthracenedione and a high potency for 1-hydroxy-4-methylanthraquinone. Thus 9, 10 anthracenedione is an effective drug againstE. coliandS. typhimuriumand 1-hydroxy-4-methylanthraquinone is effective againstS. aureusandM. luteus. The crude root extract and 9, 10 anthacenedione, 1-hydroxy-4-methylanthraquinone and 5,8-dimethoxy-2, 3, 10, 10a-tetrahydro-1H-phenanthrene-4, 9-dioneshowed a ± 50% reduction of the free radicals. No anti-inflammatory activity was observed. The purified extracts showed moderate toxicity against HepG2cells at high concentrations and no toxicity was observed against brine shrimp larvae. No mutagenicity was observed with the crude extracts using the Ames test. All purified and crude extracts showed potent inhibition of the human topoisomerase II enzyme.

【 授权许可】

Unknown