Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides

Acta Pharmaceutica Sinica B

关键词: Knoxia valerianoides;    Rubiaceae;    Anthraquinone;    Solvolytic artifacts;    HPLC–DAD–ESI–MS analysis;    Hepatocyte (WB-F344) damage protection;   

DOI  :  10.1016/j.apsb.2012.03.004

来源: DOAJ

【 摘 要 】

Eight new 9,10-anthraquinones (1–8) including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones (6–8) were isolated from an ethanol extract of the roots of Knoxia valerianoides. On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC–DAD–ESI–MS analysis of the extracts, the previously and newly isolated 2-methoxymethyl- and 2-ethoxymethyl-9,10-anthraquinones (4, 5, and 9–13), as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives (6–8), were shown to be solvolytic artifacts. In the in vitro assays, compound 4 was active to protect hepatocyte (WB-F344) damage.

【 授权许可】

Unknown