Role of Phoenix dactylifera in ameliorating Eimeria papillata-induced hepatic injury in mice

Dynamic Chiropractic

Mohamed A. Dkhil¹  Mahmoud S. Metwaly² 

[1] Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.;Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

关键词: Date fruit;    liver;    Eimeria papillata;    mice.;   

DOI  :  10.5897/JMPR11.1712

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Phoenixdactylifera(Date) is used in traditional medicine for its pharmacological properties. Here, we investigated the effects of Khodary date fruit on the outcome of coccidiosis caused byEimeria papillatain mice. Coccidiosis was induced by infection of mice with 1.5 × 103sporulated oocysts ofE. papillata. The aqueous extract of date fruit (4 ml/kg) was usedin vivofor its hepatoprotective properties. Anticoccidial and anti-inflammatory activities of date fruit were determined through oocyst output and liver histopathology, respectively. The data showed that mice infected withE. papillatarevealed an output of about 8.7 × 103oocysts per gram faeces on day 4 post -inoculation (p.i.). This output significantly decreased to about 6.7 × 103oocysts in date fruit-treated mice. Infection caused a marked liver injury as indicated by histopathological alterations as well as the significant increase in liver glutamic pyruvatetransaminase(GPT) and alkaline phosphatase (ALP). Also, infection induced a significant increase in total protein and total lipids. The aqueous extract ofP. dactyliferafruit showed a significant (P ≤ 0.05) hepatoprotective potential by improving the aforementioned parameters. Based on these results, it is concluded that date fruit could offer protection against hepatotoxicity as well as ameliorate preexisting liver damage.

【 授权许可】

Unknown