Garlic-mode treatment effects on rat brain redox status

Dynamic Chiropractic

Nadia Limam#¹  Sonia Hamlaoui-Gasmi²  Meherzia Mokni³ 

[1] des Sciences de Tunis, Campus Universitaire Manar II 2092 Tunis, Tunisia.;Laboratoire de Neurophysiologie Fonctionnelle et Pathologies, FacultéLaboratoire des Substances Biologiquement Actives, Centre de Biotechnologie, Technopole Borj-Cedria, BP 901, 2050 Hammam-Lif, Tunis, Tunisia.

关键词: Garlic;    brain;    redox status;    administration route;    lipoperoxidation;    free iron;    hydrogen peroxide;    antioxidant enzymes.;   

DOI  :  

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Garlic (Allium sativum) has played an important medicinal role in human history. We analyzed the ability of high dosage garlic administered per orally(PO) or via intraperitoneal (IP)route to act on brain antioxidant status in rats. In this organ, PO garlic is antioxidant as it decreased malondialdehyde (MDA), hydrogen peroxide (H2O2) and lactate dehydrogenase (LDH) levels. As a confirmation, oral garlic increases antioxidant enzyme activity as catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD). IP garlic is pro-oxidant as revealed by high MDA, H2O2and LDH levels. However, IP garlic decreases CAT and SOD activities but unexpectedly it has no effect on POD activity. Garlic also increases brain free iron level whatever its mode of administration however this increase is more important with IP way than PO. In conclusion, in the brain, high garlic dosage is safer when orally administered; these effects are free iron mediated and organ specific.

【 授权许可】

Unknown