The effects on motor behaviour and short-term memory tasks in mice following an acute administration of Mitragyna speciosa alkaloid extract and mitragynine

Dynamic Chiropractic

Ammar Imad Hazim¹  Muzaimi Mustapha² 

[1] Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang, Malaysia.;Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia,

关键词: Mitragyna speciosa;    mitragynine;    motor behaviour;    short-term memory;    Y-maze;    rota-rod.;   

DOI  :  

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Mitragyna speciosaKorth. leaves have been traditionally used by Malay and Thai natives for its opium-like effect and coca-like stimulant ability to enhance tolerance for hard work. Mitragynine is the major indole alkaloid in this plant. In the present study, we investigated the effects of the alkaloid extract ofM. speciosaleaves and its major alkaloid mitragynine on exploratory behaviour, short-term memory and motor coordination in mice using Y-maze and rota-rod tests, respectively. Male Swiss albino mice were orally administrated with 20, 40 and 80 mg/kg alkaloid extract ofM. speciosaleaves or mitragynine. Acute oral administration of the alkaloid extract or mitragynine significantly increased the total number of arm entries, rearing frequency and decreased grooming and immobility time in Y-maze test when compared to control group (P<0.05). However, the alkaloid extract or mitragynine did not affect short-term memory or motor coordination. These findings suggest that acute administration ofM. speciosaalkaloid extract or mitragynine may enhance exploratory behaviour due to the decrease in stress to a novel environment.

【 授权许可】

Unknown