AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYST

Journal of The Chilean Chemical Society

MAHAJAN, PRAVINS¹  NIKAM, MUKESH D¹  CHATE, ASHA V¹  GILL, CHARANSINGHH¹  DABHADE, SANJAYK¹ 

[1] Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India

关键词: Multicomponentreaction;    Dihydropyrano[;    2;    3-;    c];    pyrazoles;    Green chemistry;    Aqueous medium;    Ultrasound irradiation.;   

DOI  :  10.4067/S0717-97072015000100016

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

A green and expedient approachfor the synthesis of dihydropyrano[2,3-c] pyrazoles viafour-component reaction of ethyl acetoacetate, hydrazine hydrate, aromaticaldehydes and malononitrile at room temperature under ultrasound irradiationis described. The reaction has been catalyzed by thiamine hydrochloride in aqueousmedium. This protocol afforded several advantages such as inexpensive, easilyavailable catalyst, simple operational procedure, excellent yield, use of aqueousmedium and ultrasound irradiation that is considered to be relatively eco-friendly.

【 授权许可】

Unknown