Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8+ T Cells

PLoS Pathogens

Kirstin M. Heutinck¹  Mariet C. W. Feltkamp¹  Michiel C. van Aalderen¹  Frederike J. Bemelman²  Ester B. M. Remmerswaal³  René A. W. van Lier³  Neelke C. van der Weerd³  Ineke J. M. ten Berge³  Anja ten Brinke³  Karlijn A. M. I. van der Pant⁴ 

[1] Department of Experimental Immunology, Amsterdam, the Netherlands;Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands;Renal Transplant Unit, Division of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands;Sanquin Blood Supply Foundation and Landsteiner laboratory, Amsterdam, the Netherlands

关键词: T cells;    Cytotoxic T cells;    Viral load;    Cell differentiation;    Viral replication;    Renal transplantation;    Cytokines;    Blood;   

DOI  :  10.1371/journal.ppat.1005903

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Polyomavirus BK (BKPyV) frequently reactivates in immunosuppressed renal transplant recipients (RTRs) and may lead to graft loss due to BKPyV-induced interstitial nephritis (BKVN). Little is known on the differentiation of CD8+ T cells targeting BKPyV in RTRs. Here we investigated whether BKPyV-specific CD8+ T cell differentiation differs in RTRs with varying degrees of BKPyV reactivation and/or BKVN.

【 授权许可】

CC BY