Spectrophotometric determination of hexamethylenetetramine (HMT) in pharmaceutical preparations using chromotropic acid and microwave oven

Quimica nova

Pezza, Leonardo¹  Pezza, Helena Redigolo¹  Fagnani, Enelton² 

[1] Universidade Estadual Paulista, Araraquara, Brasil;Universidade Estadual de Campinas, Campinas, Brasil

关键词: hexamethylenetetramine;    chromotropic acid;    microwave oven.;   

DOI  :  10.1590/S0100-40422009000900039

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This paper proposesa methodology for spectrophotometric determination of hexamethylenetetramine(HMT) by using chromotropic acid in a phosphoric acid media employing a domesticmicrowave oven as a source of heating. The reddish-purple soluble product isquantitatively formed after 30 s of irradiation and obeys the Beer´s lawin the range between 0.1-1.2 mg L-1 HMT (r = 0.99925). The methodwas applied successfully in commercial pharmaceutical preparations containingdyes in their composition. The results showed that the method proposed is feasiblefor simplicity, speed, low cost, precision and accuracy when compared with UnitedStates Pharmacopeia official method.

【 授权许可】

CC BY