Synthesis of resorcinolic lipids bearing structural similarities to cytosporone A

Quimica nova

Beatriz, Adilson¹  Santos, Edson dos Anjos dos¹  Lima, Dênis Pires de¹  Marques, Maria Rita¹  Leite, Carla Braga¹ 

[1] Universidade Federal Mato Grosso do Sul, Campo Grande, Brasil

关键词: resorcinolic lipid;    cytosporone A;    allelopathic activity.;   

DOI  :  10.1590/S0100-40422009000700032

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Inspired by thestructure and biological activities of resorcinolic lipids and, particularlycytosporone A- a potent inhibitor of plantule germination and growth, we haveperformed the synthesis of the analogs 3-heptyl-3-hydroxy-5,7-dimethoxy-2-benzofuran-1(3H)-one(1) and 3-heptyl-3-hydroxy-4,6-dimethoxy-2-benzofuran-1(3H)-one (2).The intermediates and products were submitted to allelopathic test using Lactucasativa L. seeds. Target compound 1 showed an inhibitory effect ongermination and growth of hypocotyl and radicle in milimolar range.

【 授权许可】

CC BY