Yersinia pestis Activates Both IL-1β and IL-1 Receptor Antagonist to Modulate Lung Inflammation during Pneumonic Plague

PLoS Pathogens

Roger D. Pechous¹  Vijay Sivaraman²  William E. Goldman²  Edward A. Miao²  Kara R. Eichelberger²  Nikolas M. Stasulli² 

[1] Department of Biology, North Carolina Central University, Durham, North Carolina, United States of America;Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

关键词: Yersinia pestis;    Inflammasomes;    Respiratory infections;    Pneumonic plagues;    Cytokines;    Inflammation;    Inflammatory diseases;    Bacterial pathogens;   

DOI  :  10.1371/journal.ppat.1004688

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Pneumonic plague is the most rapid and lethal form of Yersinia pestis infection. Increasing evidence suggests that Y. pestis employs multiple levels of innate immune evasion and/or suppression to produce an early “pre-inflammatory” phase of pulmonary infection, after which the disease is highly inflammatory in the lung and 100% fatal. In this study, we show that IL-1β/IL-18 cytokine activation occurs early after bacteria enter the lung, and this activation eventually contributes to pulmonary inflammation and pathology during the later stages of infection. However, the inflammatory effects of IL-1β/IL-1-receptor ligation are not observed during this first stage of pneumonic plague. We show that Y. pestis also activates the induction of IL-1 receptor antagonist (IL-1RA), and this activation likely contributes to the ability of Y. pestis to establish the initial pre-inflammatory phase of disease.

【 授权许可】

CC BY