P-glycoprotein and multidrug resistance: structure-activity relationships of modulators

Quimica nova

Maruiama, Cintia H.¹  Almeida, Wanda P.¹  Huber, Paula C.¹ 

[1] Universidade Estadual de Campinas, Campinas, Brasil

关键词: P-glycoprotein;    multidrug resistance;    modulators.;   

DOI  :  10.1590/S0100-40422010001000027

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Multidrug resistance,MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugsthat vary in their chemical structure and main biological activity. Many effortshave been done to overcome MDR based on studies of structure-activity relationshipsand in this review we summarize some aspects of MDR mediated by P-glycoprotein(P-gp), as the most experimentally and clinically tested form of drug resistance.The most significant MDR mechanisms revealed until now are shortly discussed.Physicochemical and structural properties of MDR modulators, measures of theMDR reversal, and QSAR studies are included.

【 授权许可】

CC BY