SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE

Journal of The Chilean Chemical Society

GUAN, XIAO-LIN¹  FU, CHUAN¹  LEI, YAN¹  Li, TING-ZHEN¹  TAN, YAO¹ 

[1] Chongqing Three Gorges University, Chongqing, P. R. China

关键词: Synthesis;    crystal structure;    hydrazone compound;    hydrogen bonding;    antibacterial activity.;   

DOI  :  10.4067/S0717-97072015000200021

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

A series of hydrazone compounds, 4-methyl-N'-(4-nitrobenzylidene)benzohydrazide methanol solvate (1), N'-(4-hydroxy-3-nitrobenzylidene)-4-methylbenzohydrazide dimethanol solvate (2), and N'-(3,5-dibromobenzylidene)-4-methylbenzohydrazide (3), derived from 4-methylbenzohydrazide with different benzaldehydes, were synthesized and characterized by physico-chemical methods and single crystal X-ray diffraction. Crystals of the compounds are stabilized by intermolecular hydrogen bonds, as well as π···π stacking interactions. Antibacterial activity of the compounds against Staphylococcus aureus, Escherichia coli, and Klebsielle pneumoniae strains was studied. Compounds 1 and 2 have moderate minimum inhibition concentration values on the tested bacteria strains. Compound 3, with the Br-substituent groups, showed the highest activity on the bacterial strains.

【 授权许可】

Unknown