In vivo analgesic, antipyretic, and anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic extract from Litsea glutinosa leaves

Biological research: BR

Binayok Das¹  Md Siddiqul Islam²  Syed Masudur RahmanDewan³  Abhijit Das³  Rumpa Bhowmick³  Mohammad Safiqul Islam³  Md Shahid Sarwar⁴  Mir Muhammad NasirUddin⁵ 

[1] Department of Oncology, Ashic Oncology and Palliative Care Center, Dhaka, Bangladesh;Department of Pharmacy, Manarat International University, Dhaka, Bangladesh;Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh;Department of Pharmacy, Southeast University, Dhaka, Bangladesh;Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh

关键词: Acetic acid induced writhing;    Analgesic;    Anti-inflammatory;    Antipyretic;    Litsea glutinosa;    Thrombolytic;   

DOI  :  10.1186/0717-6287-47-56

学科分类：生物科学（综合）

来源: BioMed Central

【 摘 要 】

The study was conducted to evaluate the in vitro thrombolytic activity, and in vivo analgesic, anti-inflammatory and antipyretic potentials of different hydrocarbon soluble extracts of Litsea glutinosa leaves for the first time widely used in the folkloric treatments in Bangladesh. This work aimed to create new insights on the fundamental mechanisms of the plant extracts involved in these activities. In thrombolytic activity assay, a significant clot disruption was observed at dose of 1 mg/mL for each of the extracts (volume 100 μL) when compared to the standard drug streptokinase. The n-hexane, ethyl acetate, chloroform, and crude methanolic extracts showed 32.23 ± 0.26, 37.67 ± 1.31, 43.13 ± 0.85, and 46.78 ± 0.9% clot lysis, respectively, whereas the positive control streptokinase showed 93.35 ± 0.35% disruption at the dose of 30,000 I.U. In hot plate method, the highest pain inhibitory activity was found at a dose of 500 mg/kg of crude extract (15.54 ± 0.37 sec) which differed significantly (P

【 授权许可】

CC BY