SYNTHESIS, STRUCTURES, AND ANTIBACTERIAL ACTIVITIES OF 3-CHLORO-N'-(2-HYDROXY-5-METHOXYBENZYLIDENE)BENZOHYDRAZIDE AND N'-(2-HYDROXY-5-METHOXYBENZYLIDENE)-3-METHYLBENZOHYDRAZIDE

Journal of The Chilean Chemical Society

XUE, LING-WEI¹  HU, XIAO-MING¹  ZHAO, GAN-QING¹  YANG, WEI-CHUN¹ 

[1] Pingdingshan University, Pingdingshan, China

关键词: Hydrazone;    crystal structure;    hydrogen bonds;    X-;    ray crystallography;    antibacterial activity;    antifungal activity.;   

DOI  :  10.4067/S0717-97072015000300004

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

By reaction of 5-methoxysalicylaldehyde with 3-chlorobenzohydrazide and 3-methylbenzohydrazide, respectively, two structurally similar hydrazone compounds, 3-chloro-N'-(2-hydroxy-5-methoxybenzylidene)benzohydrazide (1) and N'-(2-hydroxy-5-methoxybenzylidene)-3-methylbenzohydrazide (2), were synthesized. The compounds were characterized by elemental analyses, infrared and UV-vis spectra, and single crystal X-ray diffraction. The crystal of 1 crystallizes in monoclinic space group P2/n, with unit cell dimensions a = 5.8872(8) Å, b = 31.649(2) Å, c = 7.6309(9) Å, β = 94.427(2)°, V = 1417.6(3) Å3, Z = 4, R1 = 0.0462, wR2 = 0.1053. The crystal of 2 crystallizes in orthorhombic space group Pbca, with unit cell dimensions a = 10.415(1) Å, b = 9.781(1) Å, c = 29.548(2) Å, V = 3010.2(5) Å3, Z = 8, R1 = 0.0519, wR2 = 0.1577. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger and Candida albicans) activities by MTT method.

【 授权许可】

Unknown