Genetic Epidemiology of Tuberculosis Susceptibility: Impact of Study Design

PLoS Pathogens

Catherine M. Stein¹ 

[1] Department of Epidemiology and Biostatistics, and Tuberculosis Research Unit, Case Western Reserve University, Cleveland, Ohio, United States of America

关键词: Tuberculosis;    Mycobacterium tuberculosis;    Genetic epidemiology;    Infectious disease control;    Genetics of disease;    Tuberculosis diagnosis;    management;    Diagnostic medicine;    Toll-like receptors;   

DOI  :  10.1371/journal.ppat.1001189

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Several candidate gene studies have provided evidence for a role of host genetics in susceptibility to tuberculosis (TB). However, the results of these studies have been very inconsistent, even within a study population. Here, we review the design of these studies from a genetic epidemiological perspective, illustrating important differences in phenotype definition in both cases and controls, consideration of latent M. tuberculosis infection versus active TB disease, population genetic factors such as population substructure and linkage disequilibrium, polymorphism selection, and potential global differences in M. tuberculosis strain. These considerable differences between studies should be accounted for when examining the current literature. Recommendations are made for future studies to further clarify the host genetics of TB.

【 授权许可】

CC BY