The Pseudomonas Quinolone Signal (PQS) Balances Life and Death in Pseudomonas aeruginosa Populations

PLoS Pathogens

Susanne Häussler¹  Tanja Becker¹ 

[1] Department of Cell Biology, Helmholtz Center for Infection Research, Braunschweig, Germany

关键词: Pseudomonas aeruginosa;    Antioxidants;    Vitamin C;    Cellular stress responses;    Antibiotics;    DNA fragmentation;    Reactive oxygen species;    Operons;   

DOI  :  10.1371/journal.ppat.1000166

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

When environmental conditions deteriorate and become inhospitable, generic survival strategies for populations of bacteria may be to enter a dormant state that slows down metabolism, to develop a general tolerance to hostile parameters that characterize the habitat, and to impose a regime to eliminate damaged members. Here, we provide evidence that the pseudomonas quinolone signal (PQS) mediates induction of all of these phenotypes. For individual cells, PQS, an interbacterial signaling molecule of Pseudomonas aeruginosa, has both deleterious and beneficial activities: on the one hand, it acts as a pro-oxidant and sensitizes the bacteria towards oxidative and other stresses and, on the other, it efficiently induces a protective anti-oxidative stress response. We propose that this dual function fragments populations into less and more stress tolerant members which respond differentially to developing stresses in deteriorating habitats. This suggests that a little poison may be generically beneficial to populations, in promoting survival of the fittest, and in contributing to bacterial multi-cellular behavior. It further identifies PQS as an essential mediator of the shaping of the population structure of Pseudomonas and of its response to and survival in hostile environmental conditions.

【 授权许可】

CC BY