LipidII: Just Another Brick in the Wall?

PLoS Pathogens

Menno B. Tol¹  Dirk-Jan Scheffers¹ 

[1] Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands

关键词: Lipids;    Artificial membranes;    Antibacterials;    Cell walls;    Integral membrane proteins;    Peptidoglycans;    Antimicrobial resistance;    Bacillus subtilis;   

DOI  :  10.1371/journal.ppat.1005213

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Nearly all bacteria contain a peptidoglycan cell wall. The peptidoglycan precursor molecule is LipidII, containing the basic peptidoglycan building block attached to a lipid. Although the suitability of LipidII as an antibacterial target has long been recognized, progress on elucidating the role(s) of LipidII in bacterial cell biology has been slow. The focus of this review is on exciting new developments, both with respect to antibacterials targeting LipidII as well as the emerging role of LipidII in organizing the membrane and cell wall synthesis. It appears that on both sides of the membrane, LipidII plays crucial roles in organizing cytoskeletal proteins and peptidoglycan synthesis machineries. Finally, the recent discovery of no less than three different categories of LipidII flippases will be discussed.

【 授权许可】

CC BY