Interaction between Salmonella and Schistosomiasis: A Review

PLoS Pathogens

Amber Hsiao¹  Hye Jin Seo¹  Florian Marks¹  Trevor Toy² 

[1] International Vaccine Institute, Department of Epidemiology, Republic of Korea;Technische Universität Berlin, Department of Health Care Management, Berlin, Germany

关键词: Salmonella;    Schistosomiasis;    Salmonellosis;    Typhoid;    Salmonella typhi;    Salmonella typhimurium;    Schistosoma mansoni;    Schistosoma;   

DOI  :  10.1371/journal.ppat.1005928

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

The interaction between schistosomiasis and Salmonella is a particularly important issue in Africa, where dual infection by the parasite and the bacterium are likely common. In this review, the ways in which schistosomiasis affects human biology as it relates to Salmonella are described. Those who are infected by both organisms experience reduced immunological functioning, exhibit irreversible organ damage due to prolonged schistosomiasis infection, and become latent carriers of Salmonella enterica serotypes Typhi and Paratyphi and S. Typhimurium. The sequestration of the bacteria in the parasite leads to ineffective antibiotic treatment because the bacteria cannot be completely killed, and lingering infection may then lead to antimicrobial resistance. These manifestations are likely not just for those dually infected but also for those first infected with schistosomes and, later, Salmonella. More data are needed to better understand dual infection, particularly as it may impact treatment and prevention of schistosomiasis and Salmonella in sub-Saharan Africa.

【 授权许可】

CC BY