Riboflavin: a multifunctional vitamin

Quimica nova

Ferreira, Carmen Veríssima¹  Jucá, Marilena Bezerra¹  Aoyama, Hiroshi¹  Souza, Ana Carolina Santos de¹  Cavagis, Alexandre D. Martins²  Peppelenbosch, Maikel P.² 

[1] Universidade Estadual de Campinas, Campinas;University of Groningen, The Netherlands

关键词: riboflavin;    electron transfer;    oxidative stress.;   

DOI  :  10.1590/S0100-40422005000500028

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Riboflavin, acomponent of the B2 vitaminic complex, plays important roles in biochemistry,especially in redox reactions, due to the ability to participate in both one-and two-electron transfers as well as acting as a photosensitizer. Accordingly,low intakes of this vitamin have been associated with different diseases, includingcancer and cardiovascular diseases. Riboflavin is thought to contribute to oxidativestress through its capacity to produce superoxide but, interestingly, it canalso promote the reduction of hydroperoxides. This peculiar and multifunctionalbehavior allows riboflavin to take part in various biochemical pathways as anucleophile and an electrophile, turning it into a versatile and important biologicalcompound.

【 授权许可】

CC BY