Riboflavin: a multifunctional vitamin

Química Nova

Ferreira, Carmen Veríssima¹  Jucá, Marilena Bezerra¹  University of Groningen, The Netherlands¹  Cavagis, Alexandre D. Martins¹  Aoyama, Hiroshi¹  Peppelenbosch, Maikel P.¹  Souza, Ana Carolina Santos de¹  Universidade Estadual de Campinas, Campinas¹ 

关键词: riboflavin;    electron transfer;    oxidative stress.;   

DOI  :  10.1590/S0100-40422005000500028

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Riboflavin, a component of the B2 vitaminic complex, plays important roles in biochemistry, especially in redox reactions, due to the ability to participate in both one- and two-electron transfers as well as acting as a photosensitizer. Accordingly, low intakes of this vitamin have been associated with different diseases, including cancer and cardiovascular diseases. Riboflavin is thought to contribute to oxidative stress through its capacity to produce superoxide but, interestingly, it can also promote the reduction of hydroperoxides. This peculiar and multifunctional behavior allows riboflavin to take part in various biochemical pathways as a nucleophile and an electrophile, turning it into a versatile and important biological compound.

【 授权许可】

Unknown