Preconceptual Zika virus asymptomatic infection protects against secondary prenatal infection

PLoS Pathogens

Tony T. Jiang¹  Makayla R. Braunlin¹  Lucien H. Turner¹  Giang Pham¹  Jeremy M. Kinder¹  Adrienne Wilburn¹  Sing Sing Way²  Rahul J. D’Mello² 

[1] Division of Infectious Diseases and Perinatal Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, United States of America;Immunology Graduate Program, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

关键词: Antibodies;    Zika virus;    T cells;    Comparative genomics;    Mammalian genomics;    Interferons;    Cloning;    Cytomegalovirus infection;   

DOI  :  10.1371/journal.ppat.1006684

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Pregnant women, and their fetal offspring, are uniquely susceptible to Zika virus and other microbial pathogens capable of congenital fetal infection. Unavoidable exposure to Zika virus in endemic areas underscores the need for identifying at-risk individuals, and protecting expecting mothers and their fetal offspring against prenatal infection. Here we show that primary Zika virus asymptomatic infection in mice confers protection against re-infection, and that these protective benefits are maintained during pregnancy. Zika virus recovery was sharply reduced in maternal tissues and amongst fetal concepti after prenatal challenge in mothers with resolved subclinical infection prior to pregnancy compared with mice undergoing primary prenatal infection. These benefits coincide with expanded accumulation of viral-specific antibodies in maternal serum and fetal tissues that protect against infection by the identical or heterologous Zika virus genotype strains. Thus, preconceptual infection primes Zika virus-specific antibodies that confer cross-genotype protection against re-infection during pregnancy.

【 授权许可】

CC BY