Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats

Biological research: BR

Lei Wang²  Xuebing Cao³  Shengang Sun⁴  Qineng Ping⁵  Dongzhi Hou⁶  Sai Li⁶  Yan Xu⁶ 

[1] College of Pharmacy, China Pharmaceutical University, Nanjing, People’College of pharmacy, Guangdong Pharmaceutical University, Guangzhou, People’Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’Department of Neurology, Weifang People’s Hospital, Weifang, People’s Republic of China

关键词: Dyskinesia;    Levodopa liposomes;    ERK1/2;    DARPP-32;    FosB/ΔFosB;   

DOI  :  10.1186/s40659-016-0093-4

学科分类：生物科学（综合）

来源: BioMed Central

【 摘 要 】

Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery systems is being actively researched and reported in the literature. In this study, we used chitosan-coated levodopa liposomes to investigate the behavioral character and the expression of phosphorylated extracellular signal-regulated kinase (ERK1/2), dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) and FosB/ΔFosB in striatum of rat model of levodopa-induced dyskinesia (LID). We found that scores of abnormal involuntary movement (AIM) decreased significantly in liposome group (P 

【 授权许可】

CC BY