期刊论文详细信息
Quimica nova
Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
Rahman, Habibur1  Khatoon, Asma1  Rahman, Nafisur1 
[1] Aligarh Muslim University, Pradesh, India
关键词: haloperidol;    ion-pair complex;    spectrophotometry.;   
DOI  :  10.1590/S0100-40422012000200028
学科分类:化学(综合)
来源: Sociedade Brasileira de Quimica
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【 摘 要 】

A spectrophotometricmethod based on the formation of ion-pair complex between haloperidol and eriochromeblack T (EBT) at pH 1.85 has been described. The formed complex was extractedquantitatively into chloroform and measured at 510 nm. Infra red (IR) studieswere performed to confirm the formation of ion-pair complex. Beer's law wasobeyed in the concentration range of 2.0-9.0 µg mL-1 with molarabsorptivity of 2.67 × 104 L mol-1 cm-1.The detection limit was found to be 0.18 µg mL-1. Statisticalcomparison of the results of the proposed method with those of the referencemethod shows excellent agreement and indicates no significant difference inaccuracy and precision.

【 授权许可】

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