Is Antigenic Sin Always “Original?” Re-examining the Evidence Regarding Circulation of a Human H1 Influenza Virus Immediately Prior to the 1918 Spanish Flu

PLoS Pathogens

Matthew S. Miller¹  Joaquin Madrenas²  J. Enrique Acosta³  Alain Gagnon³ 

[1] Department of Biochemistry and Biomedical Sciences, Institute for Infectious Diseases Research, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada;Department of Microbiology and Immunology and Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec, Canada;Département de Démographie, Université de Montréal, Montreal, Quebec, Canada

关键词: Antibodies;    Death rates;    Influenza viruses;    H1N1;    Influenza;    Antigenic variation;    Immune response;    Elderly;   

DOI  :  10.1371/journal.ppat.1004615

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

CC BY