Seroprevalence of 34 Human Papillomavirus Types in the German General Population

PLoS Pathogens

Heiner Boeing¹  Ulrich Reidel²  Peter Sehr²  Tim Waterboer²  Jörg Schlehofer²  Ignacio G. Bravo²  Annette Rother²  Kristina M. Michael²  Michael Pawlita²  Barbara C. Gärtner³ 

[1] Department of Epidemiology, German Institute of Human Nutrition (DIFE) Potsdam-Rehbrücke, Nuthetal, Germany;Infection and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany;Institute for Virology, Saarland University Hospital Homburg, Homburg/Saar, Germany

关键词: Human papillomavirus;    Human papillomavirus infection;    Antibodies;    Enzyme-linked immunoassays;    Warts;    HPV-1;    Serology;    Age groups;   

DOI  :  10.1371/journal.ppat.1000091

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

The natural history of infections with many human papillomavirus (HPV) types is poorly understood. Here, we describe for the first time the age- and sex-dependent antibody prevalence for 29 cutaneous and five mucosal HPV types from 15 species within five phylogenetic genera (alpha, beta, gamma, mu, nu) in a general population. Sera from 1,797 German adults and children (758 males and 1,039 females) between 1 and 82 years (median 37 years) were analysed for antibodies to the major capsid protein L1 by Luminex-based multiplex serology. The first substantial HPV antibody reactions observed already in children and young adults are those to cutaneous types of the genera nu (HPV 41) and mu (HPV 1, 63). The antibody prevalence to mucosal high-risk types, most prominently HPV 16, was elevated after puberty in women but not in men and peaked between 25 and 34 years. Antibodies to beta and gamma papillomaviruses (PV) were rare in children and increased homogeneously with age, with prevalence peaks at 40 and 60 years in women and 50 and 70 years in men. Antibodies to cutaneous alpha PV showed a heterogeneous age distribution. In summary, these data suggest three major seroprevalence patterns for HPV of phylogenetically distinct genera: antibodies to mu and nu skin PV appear early in life, those to mucosal alpha PV in women after puberty, and antibodies to beta as well as to gamma skin PV accumulate later in life.

【 授权许可】

CC BY