Radiopharmaceutical and Gene Therapy Program

Buchsbaum, Donald J.

University of Alabama at Birmingham, Birmingham, AL

关键词: Research Programs;    Antibodies;    Neoplasms;    Gene Therapy;    Antigens;   

DOI  :  10.2172/875908
RP-ID  :  DOE/ER/61654-1
RP-ID  :  FG02-93ER61654
RP-ID  :  875908

美国|英语

来源: UNT Digital Library

【 摘 要 】

The objective of our research program was to determine whether novel receptors can be induced in solid cancers as a target for therapy with radiolabeled unmodified peptides that bind to the receptors. The hypothesis was that induction of a high number of receptors on the surface of these cancer cells would result in an increased uptake of the radiolabeled monomeric peptides as compared to published results with radiolabeled antibodies or peptides to naturally expressed antigens or receptors, and therefore a better therapeutic outcome. The following is a summary of published results.