Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

PLoS Pathogens

Markus Radsak¹  Mona Saffarzadeh²  Dominik Hartl³  Horst von Bernuth⁴  Nikolaus Rieber⁵  Charaf Benarafa⁶  Alexander N. R. Weber⁷  Julia Skokowa⁸  Philipp Kruger⁹  Dirk Roos^1,10 

[1] 3rd Dept. of Medicine, Johannes Gutenberg-University Medical Center, Mainz, Germany;Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany;Department of Internal Medicine II, University of Tübingen, Tübingen, Germany;Department of Pediatric Pneumology and Immunology, Charité Hospital, Humboldt University, Berlin, Germany;Department of Pediatrics I, University of Tübingen, Tübingen, Germany;Fachbereich Immunologie, Labor Berlin Charité Vivantes GmbH, Berlin, Germany;Institute of Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany;Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom;Theodor Kocher Institute, University of Bern, Bern, Switzerland

关键词: Neutrophils;    Inflammatory diseases;    Inflammation;    Neutropenia;    Chemokines;    Mutation;    Bacterial pathogens;    Phagocytosis;   

DOI  :  10.1371/journal.ppat.1004651

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.

【 授权许可】

CC BY