pH DEPENDENT PULSATILE DRUG DELIVERY FOR CHRONOTHERAPEUTICS OF CARDIOVASCULAR DISEASES

Der Pharmacia Lettre

Kanugo ZAY¹ 

关键词: Kanugo ZAY;    Kochar NI;    Ch;    ewar AV;    Pulsatile;    C;    esartan cilexetil;    HPMC K15M;    Eudragit L 100;    Eudragit S 100;    FTIR;    Cardiovascular problems;   

DOI  :  

学科分类：药理学

来源: Scholars Research Library

【 摘 要 】

The objective of current investigation was to formulate an effective drug delivery system for the patients suffering from cardiovascular problems such as early rise in blood pressure, myocardial infarction and heart failure etc. To achieve this goal, pulsatile drug delivery was selected because it delivers the drug at right time and at right situation. Candesartan cilexetil was selected for pulsatile drug delivery in order to provide relief from various cardiovascular problems. Core tablets were formulated with different superdisintegrants for immediate release. Core tablets were further compression coated with various suitable combinations of hydrophilic polymer HPMC K15M and enteric polymers Eudragit L 100 and S100 respectively for definite lag time. The formulated tablets were evaluated for its micromeritics properties followed by weight variation, hardness, friability, content uniformity and in-vitro dissolution test. The drug-excipients interactions were carried out by FTIR studies. Optimized batch PT9 were also evaluated for accelerated stability studies which found to be successful.

【 授权许可】

CC BY