Transmission Pathways of Foot-and-Mouth Disease Virus in the United Kingdom in 2007

PLoS Pathogens

Daniel T. Haydon¹  Donald P. King²  Jemma Wadsworth²  Lynnette Goatley³  Nicholas Juleff³  Eleanor M. Cottam³  Sushila Maan³  John W. Wilesmith³  Nick J. Knowles³  Andrew E. Shaw³  David J. Paton³  Eoin D. Ryan³  Yanmin Li³  Narender S. Maan³  Katja Ebert³  Rebecca J. Rowlands³  Peter P. C. Mertens³  Nigel P. Ferris³ 

[1] Animal Health and Welfare, Defra, London, United Kingdom;Division of Environmental and Evolutionary Biology, University of Glasgow, Glasgow, United Kingdom;Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey, United Kingdom

关键词: Foot;    mouth disease;    Epidemiology;    Sequence analysis;    Viral genomics;    DNA sequence analysis;    Genomics;    Nucleotide sequencing;    Veterinary diseases;   

DOI  :  10.1371/journal.ppat.1000050

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Foot-and-mouth disease (FMD) virus causes an acute vesicular disease of domesticated and wild ruminants and pigs. Identifying sources of FMD outbreaks is often confounded by incomplete epidemiological evidence and the numerous routes by which virus can spread (movements of infected animals or their products, contaminated persons, objects, and aerosols). Here, we show that the outbreaks of FMD in the United Kingdom in August 2007 were caused by a derivative of FMDV O1 BFS 1860, a virus strain handled at two FMD laboratories located on a single site at Pirbright in Surrey. Genetic analysis of complete viral genomes generated in real-time reveals a probable chain of transmission events, predicting undisclosed infected premises, and connecting the second cluster of outbreaks in September to those in August. Complete genome sequence analysis of FMD viruses conducted in real-time have identified the initial and intermediate sources of these outbreaks and demonstrate the value of such techniques in providing information useful to contemporary disease control programmes.

【 授权许可】

CC BY