Decrease in hepatitis B prevalence among blood donors in Central-West Brazil

Journal of venomous animals and toxins

a de Siqueira Campos Lindenberg¹  Marina Sawada Torres¹  Marco Antonio Puga¹  Sonia Maria Fernandes-Fitts¹  André¹  Ana Rita Coimbra Motta-Castro¹  Tayana Serpa Ortiz Tanaka² 

[1] Federal University of Mato Grosso do Sul, Campo Grande, Brazil;Mato Grosso do Sul Hematology Center, Campo Grande, Brazil

关键词: Hepatitis B virus;    Prevalence;    Blood donors;   

DOI  :  10.1186/1678-9199-19-7

学科分类：药理学

来源: BioMed Central

【 摘 要 】

The aim of the present study was to estimate hepatitis B virus seroprevalence among first-time blood donors in the city of Campo Grande, Mato Grosso do Sul State, in the central-western region of Brazil. A retrospective analysis of first-time voluntary blood donor records, from January 2010 to December 2010, was conducted at the Hematology Center of Mato Grosso do Sul. The prevalence of the HBsAg and anti-HBc serological markers and their respective 95% confidence intervals were calculated. Chi-square analysis was performed between the seroprevalence previously found in 2001 and the one determined by the current study. Results were considered statistically significant if p < 0.05. Among 8,840 subjects, 269 (3.04%, 95% CI: 2.7-3.4) were positive for HBV markers. The prevalence rate of HBsAg was 0.19% (95% CI: 0.1-0.3) and anti-HBc alone was 2.85% (95% CI: 2.5-3.2). There was no statistically significant difference regarding gender. However, an important association was observed between HBV infection and older age (p < 0.01). The seroprevalence of HBV infection in first-time blood donors diminished from 2001 to 2010 (p < 0.01). Such decrease suggests an improvement in the recruitment of safe donors, the positive impact of vaccination programs and the decreasing of HBV infection prevalence in the general population.

【 授权许可】

CC BY