Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis

PLoS Pathogens

Franziska Faber¹  Yael Litvak¹  Andreas J. Bäumler¹  Mariana X. Byndloss¹  Helene L. Andrews-Polymenis²  Parameth Thiennimitr³  Luisella Spiga⁴  Sebastian E. Winter⁴  Sara Lawhon⁵ 

[1] Department of Medial Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, United States of America;Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, United States of America;Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, United States of America;Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX, United States of America

关键词: Salmonella typhimurium;    Respiratory infections;    Polymerase chain reaction;    Electron acceptors;    Fermentation;    Colon;    Gastrointestinal tract;    Operons;   

DOI  :  10.1371/journal.ppat.1006129

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Intestinal inflammation caused by Salmonella enterica serovar Typhimurium increases the availability of electron acceptors that fuel a respiratory growth of the pathogen in the intestinal lumen. Here we show that one of the carbon sources driving this respiratory expansion in the mouse model is 1,2-propanediol, a microbial fermentation product. 1,2-propanediol utilization required intestinal inflammation induced by virulence factors of the pathogen. S. Typhimurium used both aerobic and anaerobic respiration to consume 1,2-propanediol and expand in the murine large intestine. 1,2-propanediol-utilization did not confer a benefit in germ-free mice, but the pdu genes conferred a fitness advantage upon S. Typhimurium in mice mono-associated with Bacteroides fragilis or Bacteroides thetaiotaomicron. Collectively, our data suggest that intestinal inflammation enables S. Typhimurium to sidestep nutritional competition by respiring a microbiota-derived fermentation product.

【 授权许可】

CC BY