Tailored Immune Responses: Novel Effector Helper T Cell Subsets in Protective Immunity

PLoS Pathogens

Iain Comerford¹  Duncan R. McKenzie¹  Cameron R. Bastow¹  Ervin E. Kara¹  Carly E. Gregor¹  Shaun R. McColl¹  Kevin A. Fenix¹ 

[1] School of Molecular & Biomedical Science, The University of Adelaide, Adelaide, South Australia, Australia

关键词: Cell differentiation;    Cytokines;    T helper cells;    Immune response;    Mouse models;    T cells;    B cells;    Cell-mediated immunity;   

DOI  :  10.1371/journal.ppat.1003905

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Differentiation of naïve CD4+ cells into functionally distinct effector helper T cell subsets, characterised by distinct “cytokine signatures,” is a cardinal strategy employed by the mammalian immune system to efficiently deal with the rapidly evolving array of pathogenic microorganisms encountered by the host. Since the TH1/TH2 paradigm was first described by Mosmann and Coffman, research in the field of helper T cell biology has grown exponentially with seven functionally unique subsets having now been described. In this review, recent insights into the molecular mechanisms that govern differentiation and function of effector helper T cell subsets will be discussed in the context of microbial infections, with a focus on how these different helper T cell subsets orchestrate immune responses tailored to combat the nature of the pathogenic threat encountered.

【 授权许可】

CC BY