Protection from the 2009 H1N1 Pandemic Influenza by an Antibody from Combinatorial Survivor-Based Libraries

PLoS Pathogens

Richard A. Lerner¹  John Steel²  Peter Palese²  Richard Webby³  Natalia A. Ilyushina³  Adam Rubrum³  Michael Horowitz⁴  Ramesh R. Bhatt⁴  Aleksandr M. Faynboym⁴  Arun K. Kashyap⁴  Angeles Estelles⁴  Ryann E. Swale⁴  Lawrence Horowitz⁴  Raffaella Briante⁴  Pamela K. Foreman⁴  Li Xu⁴ 

[1] Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America;Departments of Microbiology and Medicine, Mount Sinai School of Medicine, New York, New York, United States of America;Infectious Diseases, St. Jude Research Hospital, Memphis, Tennessee, United States of America;Sea Lane Biotechnologies, Menlo Park, California, United States of America

关键词: Antibodies;    H1N1;    Influenza;    Swine influenza;    Influenza viruses;    H5N1;    Animal models of infection;    Prophylaxis;   

DOI  :  10.1371/journal.ppat.1000990

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Influenza viruses elude immune responses and antiviral chemotherapeutics through genetic drift and reassortment. As a result, the development of new strategies that attack a highly conserved viral function to prevent and/or treat influenza infection is being pursued. Such novel broadly acting antiviral therapies would be less susceptible to virus escape and provide a long lasting solution to the evolving virus challenge. Here we report the in vitro and in vivo activity of a human monoclonal antibody (A06) against two isolates of the 2009 H1N1 pandemic influenza virus. This antibody, which was obtained from a combinatorial library derived from a survivor of highly pathogenic H5N1 infection, neutralizes H5N1, seasonal H1N1 and 2009 “Swine” H1N1 pandemic influenza in vitro with similar potency and is capable of preventing and treating 2009 H1N1 influenza infection in murine models of disease. These results demonstrate broad activity of the A06 antibody and its utility as an anti-influenza treatment option, even against newly evolved influenza strains to which there is limited immunity in the general population.

【 授权许可】

CC BY