Vaccine Induced Protection Against Influenza: Persistence of Serum Antibodies, Vaccine Efficacy as a Function of Time, and Use of Transmission Models to Estimate Vaccine Effectiveness in Household Cohort Studies.

Influenza;Vaccine Effectiveness;Duration of Protection;Household Cohort Study;Transmission Model;Serum Antibodies;Public Health;Health Sciences;Epidemiological Science

Petrie, Joshua G.Eisenberg, Marisa Cristina ;

University of Michigan

关键词: Influenza;    Vaccine Effectiveness;    Duration of Protection;    Household Cohort Study;    Transmission Model;    Serum Antibodies;    Public Health;    Health Sciences;    Epidemiological Science;   

Others  :  https://deepblue.lib.umich.edu/bitstream/handle/2027.42/120645/jpetrie_1.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Influenza vaccine is currently the best available means of preventing influenza infection, though vaccine effectiveness can vary year to year based on factors such as match between circulating viruses and those included in the vaccine. We studied additional sources of variation in vaccine effectiveness estimates, both biological and methodological, including duration of vaccine induced protection, and model choice in household cohort studies. Duration of protection was examined by quantifying the persistence of serum antibodies and by estimating vaccine efficacy as a function of time. We also extended a model specifying household structure and within-household transmission, and compared influenza vaccine effectiveness estimates to those from Cox-proportional hazards models.