KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections

PLoS Pathogens

Lisa Jacobson¹  Gregory D Kirk¹  John Trowsdale²  James J Goedert³  Stephen J O'Brien⁴  Maureen P Martin⁵  Xiaojiang Gao⁵  Mary Carrington⁵  Ying Qi⁵  Susan Buchbinder⁶ 

[1] Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America;Department of Pathology, University of Cambridge, Cambridge, United Kingdom;Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America;Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, United States of America;Laboratory of Genomic Diversity, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, United States of America;San Francisco Department of Public Health, San Francisco, California, United States of America

关键词: AIDS;    Opportunistic infections;    NK cells;    Viral load;    HIV;    HIV infections;    HIV-1;    Immune response;   

DOI  :  10.1371/journal.ppat.0020079

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.

【 授权许可】

CC BY