Biginelli and Mannich multicomponent reactions in the undergraduate organic chemistry laboratory: a didactic approach to green chemistry principles

Quimica nova

Marques, Marcelo Volpatto¹  Sá, Marcus Mandolesi¹  Bisol, Tula Beck¹ 

[1] Universidade Federal de Santa Catarina, Florianópolis, Brasil

关键词: Mannich reaction;    Biginelli reaction;    Green Chemistry.;   

DOI  :  10.1590/S0100-40422012000800034

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The introduction of Mannich and Biginelli multicomponent reactions in a practical Organic Chemistry course is presented in this article. Procedures described in the literature were adapted for use under the simple conditions available in undergraduate laboratories and were selected on the basis of Green Chemistry principles and practicality of synthesis. The reactions are easy to carry out and all products are readily isolated as crystalline solids with yields ranging from moderate to high.

【 授权许可】

CC BY