Al2(SO4)3 IS AN EFFICIENT AND MILD ACID CATALYST FOR THE ONE-POT, FOUR-COMPONENT SYNTHESIS OF POLYHYDROQUINOLINE

Journal of The Chilean Chemical Society

KULKARNI, PRAMOD¹ 

[1] Hutatma Rajguru Mahavidyalaya, Pune, India

关键词: Aluminium sulfate;    Dimedone;    Dihydropyridine;    Ethyl acetoacetate Polyhydroquinoline;    Four components.;   

DOI  :  10.4067/S0717-97072014000100017

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

Aluminium sulfate has mild acidity, yet the acidity of aluminium sulfate is not taken advantage of in organic synthesis. Here, we utilized aluminium sulfate for the first time in a multicomponent reaction for the synthesis of polyhydroquinoline. A four-component one-pot synthesis of polyhydroquinoline was carried out by condensing dimedone, aromatic aldehyde, ethyl acetoacetate, and ammonium acetate using a catalytic amount of aluminium sulfate (10%) refluxed in ethanol. The present protocol using aluminium sulfate a mild solid catalyst has several merits, such as low cost, high yield, and shorter reaction time, with no byproducts.

【 授权许可】

Unknown