Intravital microscopy in a dorsal skinfold chamber:hemodynamics, tumor angiogenesis and inflammation

International Journal of Biomedical Research

Naphatsanan Duansak¹  Surapong Chatpun² 

[1] Division of Physiology, Department of Preclinical Science, Faculty of Medicine, Thammasat University;Institute of Biomedical Engineering, Faculty of Medicine, Prince of Songkla University

关键词: dorsal skinfold chamber;    microcirculation;    hemodynamics;    angiogenesis;   

DOI  :  10.7439/ijbr.v4i2.229

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

We review the dorsal skinfold chamber technique as used in microvascular studies, focusing on hemodynamics, tumor angiogenesis and inflammation. We discuss dorsal skinfold chamber implantation, intravital microscopy and microvascular visualization. Implications of vascular diameter, blood flow velocity and functional capillary density are discussed in the context of pathological models, such as resuscitation from hemorrhagic shock and acute anemia. We also review the process of dynamic vascularization of tumor angiogenesis. We further discuss oxygen and nitric oxide transports, as well as platelet activation and inflammation during the wound healing process.

【 授权许可】

CC BY