Arabidopsis leucine-rich repeat receptor–like kinase NILR1 is required for induction of innate immunity to parasitic nematodes

PLoS Pathogens

Divykriti Chopra¹  Mary Wanjiku Wang’ombe¹  Shahid Siddique¹  Florian M. W. Grundler¹  Muhammad Ilyas¹  Badou Mendy¹  Zoran S. Radakovic¹  Julia Holbein¹  Nick Holton²  Cyril Zipfel² 

[1] Rheinische Friedrich-Wilhelms-University of Bonn, INRES – Molecular Phytomedicine, Bonn, Germany;The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom

关键词: Nematode infections;    Seedlings;    Arabidopsis thaliana;    Gene expression;    RNA extraction;    Microarrays;    Proteases;    Plant pathogens;   

DOI  :  10.1371/journal.ppat.1006284

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Plant-parasitic nematodes are destructive pests causing losses of billions of dollars annually. An effective plant defence against pathogens relies on the recognition of pathogen-associated molecular patterns (PAMPs) by surface-localised receptors leading to the activation of PAMP-triggered immunity (PTI). Extensive studies have been conducted to characterise the role of PTI in various models of plant-pathogen interactions. However, far less is known about the role of PTI in roots in general and in plant-nematode interactions in particular. Here we show that nematode-derived proteinaceous elicitor/s is/are capable of inducing PTI in Arabidopsis in a manner dependent on the common immune co-receptor BAK1. Consistent with the role played by BAK1, we identified a leucine-rich repeat receptor-like kinase, termed NILR1 that is specifically regulated upon infection by nematodes. We show that NILR1 is essential for PTI responses initiated by nematodes and nilr1 loss-of-function mutants are hypersusceptible to a broad category of nematodes. To our knowledge, NILR1 is the first example of an immune receptor that is involved in induction of basal immunity (PTI) in plants or in animals in response to nematodes. Manipulation of NILR1 will provide new options for nematode control in crop plants in future.

【 授权许可】

CC BY