| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| CD4+CD25+CD127dimFoxp3+ T cells are cytotoxic for human neurons | |
| 关键词: granzyme B; axonal injury; cytotoxicity; Tregs ; neurodegeneration; | |
| DOI : 10.1189/jlb.1210654 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
MSlesionsarecharacterizedbydestructionofmyelinandsignificantneuronalandaxonalloss.PreliminarystudieswiththeuseofTregsinthemousemodelofMShavebeenextremelyencouraging.However,recentstudieswithhumancellshaveshownthepresenceofdifferentsubpopulationsofTcellswithintheCD4+CD25+Foxp3+Tcellphenotype,someofwhichdonothaveregulatoryfunctions.Thesefindingssuggestapotentialdifferencebetweenmouseandhumanintheregulatoryphenotype.Here,weshowthathumanactivatedCD4+CD25+Foxp3+Tcellsareneurotoxicinvitro.ThesecellsexpressedhighlevelsofthecytotoxicmoleculeGrBandhadnosuppressiveeffect.Onthecontrary,theyproducedIFN‐γandlowIL‐17,suggestingashifttowardaTH1phenotype.Thus,ourdataconfirmthepresenceofanonregulatorycytotoxicsubpopulationwithinthehumanCD4+CD25+Foxp3+Tcellsandsuggestfurtherstudiesonthehumanregulatoryphenotypepriortoanypotentialtherapeuticapplication...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901239974082ZK.pdf | 1189KB |  download |
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