The Golgi Apparatus: Panel Point of Cytosolic Ca2+ Regulation

Neuro-signals

关键词: Ca2+ regulators;    Cytosolic calcium;    Golgi apparatus;    Intracellular calcium store;   

DOI  :  10.1159/000350471

学科分类：神经科学

来源: S Karger AG

【 摘 要 】

The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca²⁺ store because different Ca²⁺ regulators, such as the inositol-1,4,5-triphosphate receptor, sarco/endoplasmic reticulum Ca²⁺-ATPase and secretory pathway Ca²⁺-ATPase, were demonstrated to localize on their membrane. The mechanisms involved in Ca²⁺ release and uptake in the GA have now been established. Here, based on careful backward looking on compartments and patterns in GA Ca²⁺ regulation, we review neurological diseases related to GA calcium remodeling and propose a modified cytosolic Ca²⁺ adjustment model, in which GA acts as part of the panel point.

【 授权许可】

CC BY-NC-ND