| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Defining the phenotype of neutrophils following reverse migration in zebrafish | |
| 关键词: granulocytes; inflammation; chemotaxis; infection; phagocytosis; | |
| DOI : 10.1189/jlb.3MA0315-105R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Stimulationofneutrophilreversemigrationpresentsanattractive,alternativetherapeuticpathwaytodrivinginflammationresolution.However,littleisknownaboutwhethertheactivityofwound‐experiencedneutrophilsisalteredandwhetherencouragingdispersalofsuchneutrophilsbackintothebodymayhaveundesirableconsequences.Thisstudyusedazebrafishtailtransectioninflammationmodel,incombinationwithaphotoconvertibleneutrophiltransgenicline,toallowinternallycontrolled,simultaneouscomparisonofreverse‐migratedneutrophilswithnaïveneutrophilsinthepresenceandabsenceofsecondaryinsult.Detailedmicroscopyrevealedthatreverse‐migratedneutrophilsexhibitedanactivatedmorphologybutrespondednormallytosecondaryinsultandareabletomountaneffectiveantimicrobialresponsetoStaphylococcusaureus.Theseresultssupportamodelinwhichreverse‐migratedneutrophilsexhibitnolong‐termbehavioralalterationsandencouragethenotionofenhancedreversemigrationasaviabletargetforpharmaceuticalmanipulation...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901239603861ZK.pdf | 1092KB |  download |
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