期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| RIP2 activity in inflammatory disease and implications for novel therapeutics | |
| 关键词: NOD2; NF‐; κ; B signaling; innate immunity; autoimmune disease; drug development; kinase inhibitor; | |
| DOI : 10.1189/jlb.0213109 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
TheroleofNOD2andRIP2ininflammatorydiseasehasbeenparadoxical.Whereasloss‐of‐functionNOD2polymorphismscauseCD,agranulomatousdiseaseofthegastrointestinaltract,gain‐of‐functionmutationscauseEOS—agranulomatousdiseaseprimarilyaffectingtheskin,joints,andeyes.Thus,gain‐of‐functionmutationsandloss‐of‐functionpolymorphismscausegranulomatousinflammatorydisease,onlyindifferentanatomiclocations.ThesituationiscomplicatedfurtherbythefactthatWTNOD2andWTRIP2activityhasbeenimplicatedindiseasessuchasasthma,inflammatoryarthritisandMS.ThisarticlereviewstherolethattheNOD2:RIP2complexplaysininflammatorydisease,withanemphasisontheinhibitionofthissignalingpathwayasanovelpharmaceuticaltargetininflammatorydisease...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901239233016ZK.pdf | 424KB |  download |
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