Microbiota—myeloid cell crosstalk beyond the gut

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: systemic immunity;    host–;    microbial interactions;    cancer;    infection;    mononuclear phagocytes;   

DOI  :  10.1189/jlb.3RI0516-222R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Thegutmicrobiotaisacomplexanddynamicmicrobialecosystemthatplaysafundamentalroleinhostphysiology.Locally,thegutcommensalmicrobes/hostsymbioticrelationshipisvitalforbarrierfortification,nutrientabsorption,resistanceagainstintestinalpathogens,andthedevelopmentandmaintenanceofthemucosalimmunesystem.Itisnowclearthattheeffectsoftheindigenousintestinalfloraextendbeyondthegut,rangingfromshapingsystemicimmuneresponsestometabolicandbehavioralfunctions.However,theunderlyingmechanismsofthegutmicrobiota/systemicimmunesysteminteractionsremainlargelyunknown.Myeloidcellsrespondtomicrobialsignals,includingthosederivedfromcommensals,andinitiateinnateandadaptiveimmuneresponses.Inthisreview,wefocusontheimpactofthegutmicrobiotaonmyeloidcellsatextraintestinalsites.Inparticular,wediscusshowcommensal‐derivedsignalsaffectsteady‐statemyelopoiesisandcellularfunctionandhowthatinfluencestheresponsetoinfectionandcancertherapy...

【 授权许可】

CC BY