| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Stromal‐derived IL‐6 alters the balance of myeloerythroid progenitors during Toxoplasma gondii infection | |
| 关键词: Hematopoiesis; bone marrow stromal cell; inflammation; | |
| DOI : 10.1189/jlb.1011527 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
Inflammationaltershematopoiesis,oftenbydecreasingerythropoiesisandenhancingmyeloidoutput.ThemechanismsbehindthesechangesandhowtheBMstromacontributestothisprocessareactiveareasofresearch.Inthisstudy,weexaminethesequestionsinthesettingofmurineToxoplasmagondiiinfection.Ourdatarevealthatinfectionaltersearlymyeloerythroiddifferentiation,blockingerythroiddevelopmentbeyondthePreMegEstage,whileexpandingtheGMPpopulation.IL‐6wasfoundtobeacriticalmediatorofthesedifferences,independentofhepcidin‐inducedironrestriction.ComparingtheBMwiththespleenshowedthatthehematopoieticresponsewasdrivenbythelocalmicroenvironment,andBMchimerasdemonstratedthatradioresistantcellsweretherelevantsourceofIL‐6invivo.Finally,directexvivosortingrevealedthatVCAM+CD146loBMstromalfibroblastssignificantlyincreaseIL‐6secretionafterinfection.ThesedatasuggestthatBMSCsregulatethehematopoieticchangesduringinflammationviaIL‐6...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201901239136061ZK.pdf | 1125KB |  download |
878987797
028-85220240
