TRAF3 as a powerful and multitalented regulator of lymphocyte functions

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: B cell;    T cell;    signal transduction;   

DOI  :  10.1189/jlb.2MR0216-063R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Thisreviewsummarizesthecurrentstateofknowledgeregardingtherolesofthesignalingadapterproteintumornecrosisfactorreceptor(TNFR)‐associatedfactor3inregulatingthefunctionsofBandTlymphocytes.InBlymphocytes,TNFR‐associatedfactor3inhibitssignalingbyTNFRsuperfamilyreceptors,Toll‐likereceptors,andinterleukin‐6R.Incontrast,signalingtoBcellsbythevirallyencodedoncogenicproteinlatentmembraneprotein1ispromotedbyTNFR‐associatedfactor3.AnimportantBcell‐specificroleforTNFR‐associatedfactor3istheinhibitionofhomeostaticsurvival,directlyrelevanttothecommonoccurrenceofTNFR‐associatedfactor3mutationsinhumanBcellmalignancies.TNFR‐associatedfactor3wasrecentlyfoundtobearesidentnuclearproteininBcells,whereitinteractswithandinhibitsgeneexpressionmediatedbythecAMPresponseelement‐bindingproteintranscriptioncomplex,includingexpressionoftheprosurvivalproteinmyeloidleukemiacelldifferentiationprotein1.InTlymphocytes,TNFR‐associatedfactor3isrequiredfornormalsignalingbytheTcellantigenreceptor,whileinhibitingsignalingbytheinterleukin‐2receptor.CytoplasmicTNFR‐associatedfactor3restrainsnuclearfactor‐κB2activationinbothTandBcells.Clinicalimplicationsandfuturedirectionsforthestudyofthiscontext‐dependentsignalingregulatorarediscussed...

【 授权许可】

CC BY